Abstract :Incidences of drug resistances have increased in the recent past and with the ongoing discoveries of new infectious diseases, medicine practice in management of infections and treatment of ailments have become a challenging situation in the medical care settings. Therefore, there is an urgent demand for a new class of antimicrobial agent with a different mode ofaction and it led medicinal chemists to explore a wide variety of chemical structures. In pursuit of this goal, research efforts have been directed towards the discovery of new chemical entities that are effective antimicrobial agents. The discovery and development of antimicrobial agents that has met with enormous success over the past few years provided many classes of natural products and semi-synthetic or synthetic compounds. Nitrogen containing heterocyclic compounds is well studied for their broad spectrum of activities. Among them quinolones and their derivatives constitute a crucial class of organic compounds which have been reported to posses versatile activities. The quinolones are a family of synthetic broad-spectrum antibiotic drugs [1-3]. Quinolones and their derivatives occur in numerous natural products, many of which possess interesting physiological and biological properties [1].